Renal Effects of Renin in Normal and Buffer-Nerve Sectioned Dogs.

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Abstract
Intravenous infusion of renin, 0.04 to 0.20 pressor units/kg per minute during osmotic (mannitol) diuresis and hydropenia, produced decreased renal plasma flow in all dogs. Glomerular filtration rate decreased by 15% in 6 normal dogs in which water and NaCl excretion also fell, while in another 4 normal dogs glomerular filtration rate did not change and water and NaCl excretion increased moderately. In all buffer-nerve sectioned dogs renin produced significant diuresis and natriuresis although glomerular filtration decreased from 4 to 9%. The pressor response to renin was greater in buffer-nerve sectioned than in normal dogs. The results suggest that renin diuresis may be due to a tubular mechanism and/or to increased renal perfusion pressure.