A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigro-striatal system of the human brain
- 1 February 1997
- journal article
- Published by Elsevier in Neuroscience Letters
- Vol. 223 (1) , 61-64
- https://doi.org/10.1016/s0304-3940(97)13389-4
Abstract
No abstract availableKeywords
Funding Information
- Ministry of Education, Culture, Sports, Science and Technology
This publication has 13 references indexed in Scilit:
- Stereospecific occurrence of a parkinsonism-inducing catechol isoquinoline, n-methyl(R)salsolinol, in the human intraventricular fluidJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1996
- A dopaminergic neurotoxin, (R)‐N‐methylsalsolinol, increases in parkinsonian cerebrospinal fluidAnnals of Neurology, 1996
- Enzymatic oxidation of the dopaminergic neurotoxin, 1 (R), 2(N)-Dimethyl-6,7-Dihydroxy-l,2,3,4-Tetrahydroisoquinoline, into 1,2(N)-Dimethyl-6,7-Dihydroxyisoquinolinium ionLife Sciences, 1995
- N-methyl(r)salsolinol produces hydroxyl radicals: Involvement to neurotoxicityFree Radical Biology & Medicine, 1995
- Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport systemJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1994
- N‐Methylation of Dopamine‐Derived 6,7‐Dihydroxy‐1,2,3,4‐Tetrahydroisoquinoline, (R)‐Salsolinol, in Rat Brains: In Vivo Microdialysis StudyJournal of Neurochemistry, 1992
- Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolinesJournal of Medicinal Chemistry, 1990
- Ratio of the R and S enantiomers of salsolinol in food and human urineJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1989
- Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's diseaseNature, 1988
- Alkaloids in mammalian tissues. 2. Synthesis of (+)- and (-)-1-substituted-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolinesJournal of Medicinal Chemistry, 1972