INHIBITION OF COMPLEMENT BY CARRAGEENIN - MODE OF ACTION EFFECT ON ALLERGIC REACTIONS AND ON COMPLEMENT OF VARIOUS SPECIES

Google Scholar
  • 1 January 1965
    • journal article
    • research article
    • Vol. 8  (3) , 291-+
Abstract
Carrageenin prevents the reaction of guinea-pig C[image] with sensitized red blood cells, probably by a direct inactivation of the C[image]1. The anti-complementary effect of carrageenin is antagonized by protamine sulphate. Marked reduction of circulating C[image] activity inguinea-pigs resulting from intravenous injection of carrageenin, does not alter their susceptibility to acute or protracted anaphylactic shock. The C[image] activities of human, guinea-pig, rabbit, rat and monkey sera are all inhibited in vitro by carrageenin.