Molecular Mechanisms of Cocaine Addiction

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Abstract
Effective medication for the treatment of cocaine overdose and addiction is a major unmet need of worldwide importance. In contrast to heroin, for which there are effective medications to treat both overdose (naloxone) and addiction (methadone), there are no pharmacologic treatments for any aspect of cocaine addiction. Recent discoveries indicating that an anti-cocaine medication is actually within reach are cause for great optimism. This work is defining specific molecular targets against which such a medication might be directed.A recent study by Giros et al.1 affirms the central importance of the dopamine-reuptake transporter in the behavioral and biochemical action of . . .