Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins
- 1 January 1994
- journal article
- Published by Springer Nature in Molecular and Cellular Biochemistry
- Vol. 138 (1) , 167-176
- https://doi.org/10.1007/bf00928459
Abstract
The actin cytoskeleton appears to be as the cellular target of various clostridial ADP-ribosyltransferases which have been described during recent years.Clostridium botulinum C2 toxin,Clostridium perfringens iota toxin andClostridium spiroforme toxin ADP-ribosylate actin monomers and inhibit actin polymerization.Clostridium botulium exoenzyme C3 andClostridium limosum exoenzyme ADP-ribosylate the low-molecular-mass GTP-binding proteins of the Rho family, which participate in the regulation of the actin cytoskeleton. ADP-ribosylation inactivates the regulatory Rho proteins and disturbs the organization of the actin cytoskeleton.Keywords
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