The Treatment of Angina Pectoris with Testosterone Propionate

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Abstract
Testosterone propionate was evaluated in 10 [male] patients with angina pectoris. Before institution of [male] hormone treatment, each patient served as his own control during a period of 2 mos. under usual medicinal treatment. Electrocardiograms before and after exercise tests were taken at the onset and the termination of the control period. In 8 patients no changes occurred. Two patients showed evidence of progressively increasing coronary insufficiency during this time. Treatment after the observation period consisted of semi-weekly injns. of 25 mg. of testosterone propionate for 8 wks. The degree to which the hormone prevented electrocardiographic alterations in response to exercise was considered an objective index of the therapeutic effect. Of the 8 patients who had shown no electrocardiographic changes during the control period, 7 responded favorably to treatment with testosterone propionate while one failed to respond. Six of the improved cases also showed electrocardiographic evidence of favorable response. The 2 patients who exhibited progressive changes during the control period failed to improve. It is concluded that patients with stationary electrocardiograms are more prone to respond to treatment with testosterone propionate than those with evidence of progressively increasing coronary insufficiency. After the initial 8 weeks'' course, further treatment with testosterone propionate varied with the individual case. A metabolic effect of testosterone propionate through its action in increasing the P and creatine content of the heart muscle is postulated. More thorough utilization of available O2 may thus result.

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