Ornidazole: a new antiprotozoal compound for treatment of Trichomonas vaginalis infection.
- 1 February 1977
- journal article
- research article
- Published by BMJ in Sexually Transmitted Infections
- Vol. 53 (1) , 44-48
- https://doi.org/10.1136/sti.53.1.44
Abstract
A new anti-protozoal compound, ornidazole, a derivative of nitroimidazole, was given in a single 2 g dose to 20 women with T. vaginalis infection. All the women were cured, but they suffered some side-effects. Plasma levels of ornidazole reached a peak 5-8 times higher than minimum inhibitory concentrations and exceeded this level for at least 36 h. It is therefore possible that a smaller dose might have had an adequate trichomonicidal effect and fewer side-effects. Further studies are in progress.This publication has 8 references indexed in Scilit:
- Sexually-transmitted diseases in women.Sexually Transmitted Infections, 1974
- Tinidazole--a new preparation for T. vaginalis infections. II. Clinical evaluation of treatment with a single oral dose.Sexually Transmitted Infections, 1974
- A clinical pattern for making an immediate-presumptive diagnosis of gonococcal infection in womenActa Dermato-Venereologica, 1974
- Treatment of trichomoniasis in the female with a single dose of tinidazole.1973
- Tetracyclines and Host-Defense MechanismsAntimicrobial Agents and Chemotherapy, 1973
- Direkte quantitative Photometrie an Dünnschicht-ChromatogrammenAngewandte Chemie, 1973
- Treatment of trichomonal vaginitis with a single oral dose of metronidazole.Sexually Transmitted Infections, 1972
- Trichomonal vaginitis treated with one dose of metronidazole.Sexually Transmitted Infections, 1971