Microbiological transformation of 9β,10α‐steroids III.: 11‐Hydroxylation and side chain degradation of 9β,10α‐steroids

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Abstract
Fermentation of 17α,21‐dihydroxy‐9β,10α‐pregn‐4‐ene‐3,20‐dione with Aspergillus ochraceus yielded 11α,17α,21‐trihydroxy‐9β,10α‐pregn‐4‐ene‐3,20‐dione and 15α,17α,21‐trihydroxy 9β,10α‐pregn‐4‐ene‐3,20‐dione. Fermentation of 9β,10α‐progesterone with Aspergillus ochraceus afforded 11α‐hydroxy‐9β,10α‐progesterone.Fermentation of the latter product with Sporomia pollaccii and Helicosporium lumbricopsis afforded 11α‐hydroxy‐9β,10α‐testosterone and 11α‐hydroxy‐9β,10α‐androst‐4‐ene‐3,17‐dione.Fermentation of 9β,10α‐testosterone with Aspergillus ochraceus yielded 11α‐hydroxy‐9β,10α‐testosterone and 11α‐hydroxy‐9β,10α‐androst‐4‐ene‐3,17‐dione.Fermentation of 17α‐hydroxy‐9β,10α‐progesterone with Aspergillus ochraceus afforded 11α,17α‐dihydroxy‐9β,10α‐progesterone and 11α‐hydroxy‐9β,10α‐androst‐4‐ene‐3,17‐dione.