Nocturnal akathisia in parkinson's disease: Treatment with clozapine

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Abstract
We present the results obtained using low doses of clozapine (mean dose 26.4 mg at bedtime) in the treatment of noctural akathisia in nine patients with Parkinson's disease for a mean period of 12.5 months. The results were excellent in all the patients. Furthermore, three patients experienced a remarkable improvement in rest tremor and in five patients the confusional state that accompanied the akathisia also disappeared. No serious side‐effects were observed. We believe that clozapine is a very useful drug for the relief of nocturnal akathisia in parkinsonian subjects.

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