Erythropoietin (Ep) Production and Kupffer Cell Alterations following Nephrectomy, Hypoxia, or Combined Nephrectomy and Hypoxia

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Abstract
Rat hepatic cells were evaluated using scintillation scanning and counting, autoradiography and planimetry under conditions favoring extrarenal Ep [erythropoietin] production. Kupffer cell activity paralleled Ep production whereas the liver parenchymal cells did not manifest significant changes. The Kupffer cell may be an extrarenal cellular site of Ep production.