Chemical modification of tylosin: Synthesis of amino derivatives at C-20 position of tylosin and demycarosyltylosin.
- 1 January 1983
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 36 (12) , 1713-1721
- https://doi.org/10.7164/antibiotics.36.1713
Abstract
Reductive aminations of the aldehyde group at C-20 position of tylosin and demycarosyltylosin (desmycosin) were carried out using primary and secondary amines in the presence of sodium cyanoborohydride. Some of these derivatives brought about higher antimicrobial [antibacterial] and ribosome-binding activities; the structure-activity relationship is discussed.This publication has 6 references indexed in Scilit:
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