Suppressant effect of procarbazine and its comparison with anti-lymphocyte serum in adjuvant-induced polyarthritis in rats.

  • 1 February 1970
    • journal article
    • research article
    • Vol. 6  (2) , 291-7
Abstract
Procarbazine, a new immunosuppressant, was active in inhibiting the lesions of experimental arthritis in rats. In comparison with anti-lymphocyte serum it was somewhat more effective in suppressing the secondary than the primary lesion of adjuvant-induced disease. The anti-inflammatory action of procarbazine could not be correlated exactly with its immunosuppressant effect. The dosage scheme which began 21 days before immunization and which had the greater effect on the immune response, did not have any greater anti-arthritic effect than the dosage scheme started on day 0.