Imposing Specificity on Kinases
- 14 February 2003
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 299 (5609) , 1025-1027
- https://doi.org/10.1126/science.1081519
Abstract
How does a cell imbue kinase signaling cascades that share some of the same components with a specificity that ensures activation of the correct cellular response? In their Perspective, Ptashne and Gann discuss the leading part played by protein scaffolds and regulated recruitment in conferring specificity on kinase signaling cascades.Keywords
This publication has 7 references indexed in Scilit:
- Rewiring MAP Kinase Pathways Using Alternative Scaffold Assembly MechanismsScience, 2003
- Cdc42 Regulation of Kinase Activity and Signaling by the Yeast p21-Activated Kinase Ste20Molecular and Cellular Biology, 2002
- The Ste5p scaffoldJournal of Cell Science, 2001
- Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteinsCurrent Biology, 2001
- Mutational Analysis Suggests That Activation of the Yeast Pheromone Response Mitogen-activated Protein Kinase Pathway Involves Conformational Changes in the Ste5 Scaffold ProteinMolecular Biology of the Cell, 2000
- Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation SwitchCell, 2000
- Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gβγ complex underlies activation of the yeast pheromone response pathwayGenes & Development, 1998