The 24‐hour pattern of serum TSH in patients with endogenous depression

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Abstract
The 24 h pattern of serum thyrotropin (TSH) was studied using hourly blood-sampling in 4 patients with severe endogenous depression. All patients showed a pattern similar to that of normal subjects, with lowest levels of serum TSH between 0900-2000 h and highest levels between 2100-0800 h. A phaseshift of the TSH rhythm can therefore not account for the previous findings of a significant negative correlation between severity of endogenous depression and night increase in serum TSH measured as the difference between the values at 2400-1400 h.