A CARDIAC ANTIARRHYTHMIC SCREENING-TEST USING THE ISOLATED ISCHEMIC PERFUSED RAT-HEART PREPARATION
- 1 January 1985
- journal article
- research article
- Vol. 277 (2) , 217-222
Abstract
Ventricular fibrillation was induced by myocardial ischemia and reperfusion in the isolated perfused rat heart. The dose-response effectiveness for the prototype antiarrhythmic drugs, propranolol, quinidine and lidocaine in converting the induced ventricular fibrillation to sinus rhythm was determined. The test is easy to perform and does not require skillful surgical procedure and long time for observation. In addition, no arrhythomgenic drugs are used and the amount of substance needed for the test is very small. It is suggested that this simple test be used as a cardiac antiarrhythmic screening test for antiarrhythmic drugs.This publication has 6 references indexed in Scilit:
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