REDISTRIBUTIONS OF WATER FOLLOWING TRANSFUSIONS AND INFUSIONS

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Abstract
Fluids in large amounts, up to 100% of the whole blood volume, were added rapidly to the blood in 21 anesthetized dogs. Initial exchanges of water between blood and tissue spaces were measured by finding what changes occurred in the concns. of blood, plasma, and tissues, sampled at frequent intervals. Using whole blood or fluids resembling the plasma the initial rates of loss of water from circulation depended chiefly on the volumes infused. Solns. of high osmotic pressure or of high colloid osmotic pressure produced more rapid trans-locations of fluid. High concns. initially attracted fluid into the blood; with high colloid osmotic pressures the fluid remained there. Chloride usually accompanied the water in its movements, redistributing itself in apparently equal concns. between the plasma and the other extracellular fluids. The most rapid entrance of water into the circulating blood was 6 cc. per kgm. of body weight per min. In a majority of exps. most of the transfer of fluid was completed before the infusion had ended.

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