A Human Cellular Protein Activity (OF-1), Which Binds Herpes Simplex Virus Type 1 Origin, Contains the Ku70/Ku80 Heterodimer
Open Access
- 15 July 2004
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (14) , 7839-7842
- https://doi.org/10.1128/jvi.78.14.7839-7842.2004
Abstract
In an effort to identify host proteins involved in herpes simplex virus type 1 replication, monkey and human cellular protein activities (called OF-1) that bind the viral replication origin, oriS, have been described. We show by mass spectrometry that the DNA-binding component of human OF-1 contains Ku70 and Ku80 proteins.Keywords
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