Familial Vitamin B12 Malabsorption

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Abstract
A report is given on the results of the SCHILLING test in 10 previously described patients suffering from an apparently selective and specific vitamin B12 malabsorption disease. Without intrinsic factor material the urinary excretion of Co58B12 was between 0 and 1.4% of the test-dose administered. There was no significant increase in the excretion when intrinsic factor material was added to the test-dose Co58B12 neither after treatment with antibiotics (arhromycin given to 5 patients) nor after prednisone (given to 3 patients). The intrinsic factor activity of the patients'' gastric juice was normal when tested on patients with pernicious anemia.