The Site of Vitamin B12-Intrinsic Factor Complex "Releasing Factor" Activity in the Rat Small Intestine
- 1 June 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 110 (2) , 315-317
- https://doi.org/10.3181/00379727-110-27502
Abstract
Radioactive vitamin B12 bound to rat gastric intrinsic factor was dialyzed at pH 7.4 and 37[degree]C for 5 hours together with the super-nate of aqueous suspensions of rat small intestinal homogenates. Because supernates from only the proximal 10% of the rat intestine caused radiovitamin to appear in the dialyzate, doubt was cast upon the previously reported (J. Clin. Invest. 39: 199-214, 1960) physiologic role of an intestinal "releasing factor" that is lacking in the mid-portion of the rat intestine where vitamin B12 is principally absorbed.Keywords
This publication has 2 references indexed in Scilit:
- Effect of Intrinsic Factor on Vit. B12 Uptake by Rat Intestine in vitro.Experimental Biology and Medicine, 1958
- MALABSORPTION SYNDROME: INTESTINAL ABSORPTION OF VITAMIN B12Annals of Internal Medicine, 1958