MONOCLONAL IMMUNOGLOBULIN RESCUE FROM A PATIENT WITH CHRONIC LYMPHOCYTIC-LEUKEMIA AND AUTO-IMMUNE HEMOLYTIC-ANEMIA
- 1 January 1979
- journal article
- research article
- Vol. 54 (2) , 513-518
Abstract
To test whether autoimmune hemolytic anemia in a patient with chronic lymphocytic leukemia was due to autoantibody production by the neoplastic clone, somatic cell hybrids were constructed between the patient''s leukemic cells and a mouse myeloma line. L chain-restricted human immunoglobulin was secreted by 4 of 11 of the established hybrid lines. No binding of this immunoglobulin to red cell surface antigens could be detected. The autoantibody in this patient apparently represented a concomitant reactive response and was not the product of the malignant clone of B [bone marrow derived] cells.This publication has 4 references indexed in Scilit:
- Rescue of immunoglobulin secretion from human neoplastic lymphoid cells by somatic cell hybridization.Proceedings of the National Academy of Sciences, 1978
- A rapid method for the preparation of high potency auto and alloantibody eluatesTransfusion, 1977
- STRUCTURAL ASPECTS OF HUMAN ERYTHROCYTE AUTOANTIBODIESThe Journal of Experimental Medicine, 1965
- Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed RecombinantsScience, 1964