Negatively supercoiled simian virus 40 DNA contains Z-DNA segments within transcriptional enhancer sequences
- 1 June 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 303 (5919) , 674-679
- https://doi.org/10.1038/303674a0
Abstract
Three 8-base pair (bp) segments of alternating purine-pyrimidine from the simian virus 40 enhancer region form Z-DNA on negative supercoiling; minichromosome DNase I-hypersensitive sites determined by others bracket these three segments. A survey of transcriptional enhancer sequences reveals a pattern of potential Z-DNA-forming regions which occur in pairs 50–80 bp apart. This may influence local chromatin structure and may be related to transcriptional activation.This publication has 46 references indexed in Scilit:
- Negatively supercoiled plasmids contain left-handed Z-DNA segments as detected by specific antibody bindingCell, 1982
- Left-handed Z-DNA is induced by supercoiling in physiological ionic conditionsNature, 1982
- Flipping of cloned d(pCpG)n.d(pCpG)n DNA sequences from right- to left-handed helical structure by salt, Co(III), or negative supercoiling.Proceedings of the National Academy of Sciences, 1982
- Antibodies specific for left-handed Z-DNA.Proceedings of the National Academy of Sciences, 1981
- In vivo sequence requirements of the SV40 early promoter regionNature, 1981
- Simian virus 40 tandem repeated sequences as an element of the early promoter.Proceedings of the National Academy of Sciences, 1981
- Molecular structure of a left-handed double helical DNA fragment at atomic resolutionNature, 1979
- SV40 viral minichromosome: preferential exposure of the origin of replication as probed by restriction endonucleasesNucleic Acids Research, 1978
- Complete nucleotide sequence of SV40 DNANature, 1978
- The Genome of Simian Virus 40Science, 1978