Prolonged Postoperative Bleeding in a Patient with Factor XI (PTA) Deficiency

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Abstract
Studies concluded that 1) although several routine coagulation tests such as venous clotting time, partial thromboplastin time, and prothrombin consumption are useful as indicators of possible PTA deficiency and to show response to initial infusion of plasma, diagnosis can be established only by specific PTA assay; and 2) once hemorrhage has occurred and large quantities of plasma have been given, bleeding may continue even at PTA levels usually considered adequate for normal hemostasis. Under these circumstances, both routine tests and assay methods may fail to give sufficient warning of incipient bleeding.