Gene conversion: remarks on the quantitative implications of hybrid DNA models

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Abstract
SUMMARY: Some quantitative implications of the gene conversion models of Holliday and Whitehouse & Hastings are discussed. These models predict two kinds of mispairing when a heterozygous mutant is in hybrid DNA. It is pointed out that the latter model, in contrast to statements in the literature, does not require identical repair rates in both kinds of mispairing.Furthermore, some peculiarities are discussed which result if, among the corrected fractions of hybrid sites, the frequency of repair to wild-type is the same in both kinds of mispairing (r=s). In the Holliday model a minimum results under this condition for the frequency of asci which show a normal 4:4 segregation, but which have originated by repair from meioses with hybrid DNA.

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