Erythroderma, palmoplantar keratoderma and profound failure to thrive in an infant

Abstract
The case is reported of a female infant, who at the age of 3 months developed severe erythroderma, marked hyperkeratosis of the palms and soles and subsequently extreme growth failure and intermittent diarrhoea. Her course was complicated by life‐threatening infections but detailed investigation revealed no recognized underlying metabolic or immune abnormality.