Neuroleptic Malignant syndrome caused by dopamine‐depleting drugs in a patient with Huntington disease

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Abstract
Prior reports of neuroleptic malignant syndrome (NMS) concerned patients with psychiatric disorders, usually schizophrenia, who were taking dopamine receptor blocking agents. The syndrome was reported in a patient with Huntington disease treated with dopamine-depleting agents. He had a negative evaluation for malignant hyperthermia (MH). The occurrence of NMS caused by dopamine-depleting agents suggested that anticholinergic properties of phenotiazines were not the only cause. Central dopaminergic systems probably participated in thermoregulation, and dopamine depletion probably played a pathogenetic role in this syndrome.