Cerebro-Circulatory Effects of So-Called ‘Vasodilators’ in the Anaesthetised Rat
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in European Neurology
- Vol. 22 (2) , 142-153
- https://doi.org/10.1159/000115551
Abstract
The cerebro-vascular effects of various agents used in the treatment of cerebral disorders (dihydroergotoxine, ifenprodil, naftidrofuryl, nicardipine, nicergoline, papaverine and vincamine) were studied in the anesthetized rat. The agents effected an increase in global cerebral blood flow, each to a different magnitude, in a dose-related manner. The changes in flow induced in the normal brain are likely to be of much relevance to the use of these compounds in the treatment of focal cerebral ischemia.Keywords
This publication has 16 references indexed in Scilit:
- The effect of papaverine on local tissue P O 2 and microflow in cat brain cortexNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1978
- Chemical control of cerebral circulationJournal of the Neurological Sciences, 1978
- COMPARATIVE ACTIVITIES OF NICERGOLINE AND PAPAVERINE ADENYLATE AND 5-PYRIDOXALPHOSPHATE ON LOCAL CEREBRAL BLOOD-FLOW OF UNANESTHETIZED RABBIT1978
- The Effect of Vincamine on the Regional Cerebral Blood Flow in ManEuropean Neurology, 1978
- Rapid and Repetitive Measurements of Blood Flow and Oxygen Consumption in the Rat Brain Using Intraarterial Xenon InjectionActa Physiologica Scandinavica, 1977
- Cerebral Blood Flow and Oxygen Consumption in Rat, Measured with Microspheres or XenonActa Physiologica Scandinavica, 1977
- Cerebral blood flow regulation. II. Vasodilator mechanisms.Stroke, 1977
- Action of vasodilators on regional cerebral blood flow in subacute or chronic cerebral ischemia.Stroke, 1977
- EFFECTS OF PAPAVERINE MONOPHOSADENINE (PAPAVERINE, 5'-ADENYLATE) ON LOCAL CEREBRAL BLOOD-FLOW IN NONANESTHETIZED ANIMAL1976
- THE EFFECTS OF DIHYDROERGOCORNINE ON THE CEREBRAL CIRCULATION OF PATIENTS WITH ESSENTIAL HYPERTENSION 1Journal of Clinical Investigation, 1950