MORPHOLOGIC ASPECTS OF EXPERIMENTAL ESOPHAGEAL LYE STRICTURES .2. EFFECT OF STEROID-HORMONES, BOUGIENAGE, AND INDUCED LATHYRISM ON ACUTE LYE BURNS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 81  (4) , 431-435
Abstract
Among 77 dogs surviving standardized transmural esophageal lye injury for at least 2 wk and as long as 12 wk, 24 were untreated, 26 received corticosteroids and bougienage (S&B) and 27 received only the lathyrogen .beta.-aminoproprionitrile (BAPN). Stricture frequency was reduced markedly and significantly in the S&B and BAPN groups when compared to the controls (P < 0.01). Strictures resulted from inward circumferential remodeling of all mural layers, not proliferating bulky scar tissue and persistent ulceration was apparently not an influential factor in any group. The S&B dogs invariably showed reduction of the internal or mucosal length of the injured segment as compared to the outer length; these relations were quite variable in the other 2 groups so that mean internal shortening was significantly greater (P < 0.01) in the S&B group. Marked mural thinning in the injured zone was present in all 3 groups but was most frequent in the BAPN-treated animals. BAPN-induced changes in the physical properties of reparative tissue can increase the ultimate caliber of an injured hollow viscus without resort to mechanical bougienage. Wound contraction may play a role in stricture formation in this model.

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