Studies of adenovirus-SV40 hybrid viruses. V. Evidence for linkage between adenovirus and SV40 genetic materials.
- 1 May 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 55 (5) , 1126-1132
- https://doi.org/10.1073/pnas.55.5.1126
Abstract
Strains of Ad. 2 and Ad. 12 to which the SV40 gene for T antigen induction was transferred by mixed infection with the Ad. 7-SV40 hybrid strain E46+ also acquired the ability to induce a T antigen of Ad. 7. The determinant for induction of the Ad. 7 antigen is in Ad. 2 or Ad. 12 capsids, is not separable from the SV40 gene by cloning, and like the SV40 DNA, is in defective particles. It is concluded that the SV40 DNA and a portion of Ad. 7 DNA are in the same capsids, and are probably linked.This publication has 13 references indexed in Scilit:
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