SV40-adenovirus "hybrid" populations: transfer of SV40 determinants from one type of adenovirus to another.

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Abstract
Plaque formation in GMK cells by an SV40-adenovirus 7 "hybrid" population can be enhanced by the addition of additional adenovirus type 7 or by other adenovirus types. The progeny from these enhanced plaques are coated by protein antigenically identical to that of the co-infecting adenovirus. These new adenovirus type "hybrid" populations (types 2, 3, 12, etc.) then breed true on further passage in GMK cells. It appears that the "hybrid" populations consist of at least two types of particles. One of these particles is the normal adenovirus and the second particle is a defective virus (termed PARA) which contains a portion of the SV40 genome and which is necessary for adenovirus replication in GMK cells. In the process of replication, PARA acquires the capsid of the helper adenovirus.

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