Pharmacologic Inhomogeneity Between the Reactivity of Intramural Coronary Arteries and Arterioles
- 1 October 2001
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 38 (4) , 584-592
- https://doi.org/10.1097/00005344-200110000-00011
Abstract
We hypothesized that because of their size, anatomic location, and hemodynamic function, coronary arteries and arterioles would respond differently to vasoactive substances. Intramural arteries (281.7 ± 23.1 μm) and arterioles (77.3 ± 6.6 μm) of the left anterior descending coronary of rats were isolated and cannulated. Spontaneous tone was lower in arteries than in arterioles (81.1 ± 5.7 vs. 53.0 ± 3.9% of passive diameter, p −8Keywords
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