Effect of Rifampin on Theophylline Disposition

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Abstract
The concentrations of theophylline from single 400-mg oral doses were evaluated both before and after 7 days of oral rifampin [an antituberculosis agent] administration (600 mg/day) in 6 healthy, nonsmoking adults. The mean oral clearance of theophylline was significantly increased from 54.9 .+-. 21.2 to 68.9 .+-. 26.5 ml/h per kg. The elimination rate constant was significantly increased in 5 of the 6 subjects, with a mean increase of .apprx. 25%. Although intersubject variability was large, these data indicate the potential need to increase theophylline doses in some patients receiving rifampin.

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