Epinephrine, norepinephrine, and isoproterenol dose‐outflow facility response relationships in cynomolgus monkey eyes with and without ciliary muscle retrodisplacement

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Abstract
Intracameral slowly mixed bolus doses of 10 μg of 1‐epinephrine or 1‐norepinephrine bitartrate significantly increased total outflow facility by similar percentages in ciliary muscle disinserted and non‐disinserted living cynomolgus monkey eyes (˜ 20% for epinephrine, 30% for norepinephrine); smaller or larger bolus doses (0.1, 1, 50 μg) either had no effect or tended to decrease facility. Bolus doses of dl‐isoproterenol sulphate (0.1, 0.2, 10, 50 μg) or I‐isoproterenol hydrochloride (0.1, 1, 10 μg) had no effect in either type of eye. Rapidly mixed relatively maintained intracameral concentrations of dl(0.1, 1 μg/ml)‐ or 1(0.1, 1, 10 μg/ml)‐isoproterenol had no effect in surgically untouched eyes. All catecholamine solutions were stable under the experimental conditions.