Aryloxyalkyloxy- and aralkyloxy-4-hydroxy-3-nitrocoumarins which inhibit histamine release in the rat and also antagonize the effects of a slow reacting substance of anaphylaxis
- 1 February 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (2) , 158-168
- https://doi.org/10.1021/jm00188a007
Abstract
The syntheses and structure-activity relationships of a number of 4-hydroxy-3-nitrocoumarins, which are antagonists of a slow reacting substance of anaphylaxis and potent inhibitors of antigen-induced histamine release in the rat, are described. Most active among these are 7-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-2-hydroxypropoxy] derivatives having hydrogen or lower alkyl substituents at the C-8 position of the coumarin ring.This publication has 2 references indexed in Scilit:
- Synthesis and antiallergic activity of 2-hydroxy-3-nitro-1,4-naphthoquinonesJournal of Medicinal Chemistry, 1977
- Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acidsJournal of Medicinal Chemistry, 1977