Modification of the hypoglycaemic response to tolbutamide and insulin by mebanazine—an inhibitor of monoamine oxidase

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Abstract
Following reports of clinical changes in the carbohydrate metabolism of diabetic patients receiving mebanazine, possible interactions between mebanazine, adrenaline, tolbutamide and insulin have been studied in rats. Mebanazine had no activity on blood sugar levels and was found to have no effect on the metabolic actions of injected adrenaline. In acute experiments, mebanazine appeared to reduce the net hypoglycaemic action of tolbutamide but had no effect on the response to insulin. In chronic experiments, mebanazine pre-treatment led to a significant potentiation of the hypoglycaemic responses both to tolbutamide and insulin. The possible mechanisms of action and the clinical implications are discussed.