Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases
Open Access
- 14 July 2008
- journal article
- Published by Springer Nature in BMC Genomics
- Vol. 9 (1) , 329
- https://doi.org/10.1186/1471-2164-9-329
Abstract
Selenoprotein S (SelS) protects the functional integrity of the endoplasmic reticulum against the deleterious effects of metabolic stress. SEPS1/SelS polymorphisms have been involved in the increased release of pro-inflammatory cytokines interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6 in macrophages. We aimed at investigating the role of the SEPS1 variants previously associated with higher plasma levels of these cytokines and of the SEPS1 haplotypes in the susceptibility to develop immune-mediated diseases characterized by an inflammatory component.Keywords
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