ENZYMES IN CANDIDA ALBICANS I

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Abstract
Since diabetic patients, in whose system the carbohydrate metabolism has been altered, are more susceptible to infection by Candida albicans than normal people, the glucose metabolism in this fungus has been investigated. Work with both whole cells and cell-free extract prepared by grinding the harvested cells with alumina has shown that the organism possesses the enzymes of both glycolytic and hexose monophosphate shunt pathways. Most of the dehydrogenases were found to be highly specific to triphosphopyridine nucleotide. Also, high activity of the glycerol and lactic dehydrogenases with equilibrium favorable to the corresponding keto compounds has been observed. These two properties of Candida albicans are presumed to be due to the highly aerobic nature of the organism.

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