Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis
- 1 March 1995
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 39 (3) , 769-770
- https://doi.org/10.1128/aac.39.3.769
Abstract
Molecular characterization of a streptomycin-dependent mutant of Mycobacterium tuberculosis revealed the presence of a novel mutation in the rrs gene encoding 16S rRNA. Insertion of an additional cytosine in the 530 loop of 16S rRNA, a region known to be involved in streptomycin susceptibility and resistance, was associated with streptomycin dependence.Keywords
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