STUDIES ON AMINO ACID METABOLISM. II. BLOOD GLYCINE AND TOTAL AMINO ACIDS IN VARIOUS PATHOLOGICAL CONDITIONS, WITH OBSERVATIONS ON THE EFFECTS OF INTRAVENOUSLY ADMINISTERED GLYCINE 1

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Abstract
Low blood glycine was observed in 1 case of subacute yellow atrophy, 1 hyperthyroid with myopathy, and 2 cases of ulcerative colitis. The lowest values were found in subjects with rheumatoid arthritis. A tendency toward elevated glycine, particularly in the erythrocytes,was found in some patients with -liver disease, chronic glomerulone-phritis, hypometabolism, polycythemia vera, and leukemia. No relation was evident between blood glycine, total alpha-amino N, protein and non-protein N. The intraven. admn. of glycine results in a rapid rise and subsequent decline in both plasma and erythro-cyte glycine. The latter lags behind the former, which, on the basis of in vitro studies, is interpreted as being due to slow diffusion of1 glycine into and out of the erythrocyte. Certain abnormalities in the glycine tolerance curve were observed in a few pathological subjects.