Teratogeneic effects of endotoxin on the golden hamster
- 1 January 1983
- journal article
- research article
- Published by Wiley in Teratogenesis, Carcinogenesis, and Mutagenesis
- Vol. 3 (2) , 145-149
- https://doi.org/10.1002/1520-6866(1990)3:2<145::aid-tcm1770030206>3.0.co;2-u
Abstract
Gram-negative urinary tract infections in pregnant women have been implicated as causes of maternal endotoxemia and a subseqent higher incidence of malformations in their offspring. A study was performed to evaluate the effects of endotoxin on the development of the golden hamster. Endotoxin was shown to be extremely embryolethal at higher doses and to produce several malformations at lower doses. The pregnant hamster and its developing embryos were observed to be far more sensitive to endotoxin than species examined by other investigators.Keywords
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