A Cell-Cycle Constraint on the Regulation of Gene Expression by Platelet-Derived Growth Factor
- 27 November 1987
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 238 (4831) , 1269-1271
- https://doi.org/10.1126/science.3685976
Abstract
In density-arrested monolayer cultures of Balb/c 3T3 cells, platelet-derived growth factor (PDGF) stimulates expression of the c- myc and c- fos proto-oncogenes, as well as the functionally uncharacterized genes, JE, KC, and JB. These genes are not coordinately regulated. Under ordinary conditions, c- fos , JE, KC, and JB respond to PDGF only when the cells are in a state of G 0 growth arrest at the time of PDGF addition. The c- myc gene is regulated in opposition to the other genes, responding best to PDGF in cycling cultures.Keywords
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