Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas

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Abstract
Comparative nucleotide sequence analysis of a rearranged c-myc gene in a murine plasmacytoma and c-myc c[complementary]DNA from normal spleen reveals that chromosomal translocation in the plasmacytoma breaks the c-myc gene within the 1st exon or intron. In the plasmacytoma truncated c-myc RNA initiate from newly exposed promoter sites. The myc polypeptide produced in the plasmacytoma is probably the same as that from the intact c-myc gene becauses the axon lost by breakage and translocation is non-coding. The 2nd and 3rd exons of the mouse c-myc gene are substantially conserved in the v-myc gene of the avian retrovirus, MC29.