The stimulation of transphosphorylation by alkali-metal ions

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Abstract
The stimulation by alkali-metal ions of a nonenzymic-phosphate transfer from adenosine triphosphate(ATP) is described. The alkali-metal-ion stimulation does not abolish the absolute requirement by the reaction for bivalent-metal ions (M++). K+ produce a greater stimulation than other alkali-metal ions at ATP/M++ ratios in the region of 1. The observed effects are discussed in terms of ion-pair and of chelate formation. The results provide a chemical basis for the alkali-metal-ion dependence or stimulation observed in many enzyme-catalyzed-phosphate-transfer reactions involving ATP and similar substances.