The Conundrum Posed by Cellular Heterogeneity in Analysis of Human Neuroblastoma

Open Access
Publisher Website
Google Scholar
Abstract
Examining the methylation patterns of gene promoters has become a powerful tool in the effort to identify and distinguish different tumor subtypes ( 1 , 2 ). Typically associated with tumor suppressor genes, epigenetic silencing of gene expression has been seen in several different cancers. Aberrant hypermethylation has been recorded for genes that function in various aspects of cancer biology, including cell cycle regulation, tumor suppression, apoptosis, and metastasis. The article by Alaminos et al. ( 3 ) in this issue is a clear extension of this previous research.