Substrate flexibility of a 2,6-dideoxyglycosyltransferase
- 1 January 2006
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 35,p. 3738-3740
- https://doi.org/10.1039/b608847c
Abstract
We report the first 2,6-dideoxysugar-O-glycosyltransferase with substrate flexibility at the 2 position, confirm the function of a putative NDP-hexose 2,3-dehydratase in the jadomycin B biosynthetic gene cluster and deduce the substrate flexibility of downstream enzymes in L-digitoxose assembly, enabling reprogramming of biosynthetic gene clusters to modify sugar substituents.Keywords
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