Introduction of a Triazole Amino Acid into a Peptoid Oligomer Induces Turn Formation in Aqueous Solution
- 17 May 2007
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 9 (12) , 2381-2383
- https://doi.org/10.1021/ol070817y
Abstract
Peptoids are a non-natural class of oligomers that are composed of repeating N-substituted glycine units and are capable of folding into helices that mimic peptide structure and function. In this letter, we report the concise synthesis of a 1,5-substituted triazole amino acid (Tzl) and its subsequent incorporation into a short peptoid. The Tzl amino acid was shown to induce turn formation in aqueous solution, thus expanding the structural repertoire available to peptoid chemists.Keywords
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