Possible role of sulfhydryls in mucosal protection induced by aluminum hydroxide
- 1 November 1986
- journal article
- research article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 31 (11) , 1207-1210
- https://doi.org/10.1007/bf01296520
Abstract
The involvement of sulfhydryl-containing compounds was investigated in the cytoprotective effect of certain antacids against ethanol-induced gastric mucosal damage in the rat. Not only the protective effect of a sulfhydryl containing compound,N-acetylcysteine, was abolished after pretreatment withN-ethylmaleimid, but also the adaptive cytoprotection induced by 20% ethanol. Pretreatment of the animals with the cyclooxygenase inhibitor indomethacin or with the thiol reagentN-ethylmaleimide significantly diminished the cytoprotection evoked by aluminum hydroxide. However, the protective effect of aluminium hydroxide could only be totally abolished by pretreatment with the combination of indomethacin andN-ethylmaleimide. The present results suggest the additional role of sulfhydryl-containing compounds localized in the gastric mucosa in the cytoprotection induced by a mild irritant or by aluminium hydroxide and aluminium hydroxidecontaining antacids as well.Keywords
This publication has 12 references indexed in Scilit:
- Early Vascular Injury and Increased Vascular Permeability in Gastric Mucosal Injury Caused by Ethanol in the RatGastroenterology, 1985
- Functional cytoprotection by certain antacids.1984
- Sucralfate protection of the gastric mucosa against ethanol-induced injury: a prostaglandin-mediated process?1984
- Distinction between antiulcer effect and cytoprotection.1984
- Evidence for a functional cytoprotective effect produced by antacids in the rat stomachEuropean Journal of Pharmacology, 1983
- Manual of Pharmacologic Calculations with Computer Programs.Journal of the Royal Statistical Society Series C: Applied Statistics, 1982
- Sulfhydryl Compounds May Mediate Gastric CytoprotectionScience, 1981
- Prevention by mild irritants of gastric necrosis produced in rats by sodium taurocholateDigestive Diseases and Sciences, 1980
- Cytoprotection by prostaglandinsGastroenterology, 1979
- CYTO-PROTECTION BY PROSTAGLANDINS IN RATS - PREVENTION OF GASTRIC NECROSIS PRODUCED BY ALCOHOL, HCL, NAOH, HYPERTONIC NACL, AND THERMAL-INJURY1979