STRAIN-LINKED AND SEX-LINKED EFFECTS OF DIETARY POLY-UNSATURATED FATTY-ACIDS ON TUMOR-GROWTH AND IMMUNE FUNCTIONS IN MICE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (10) , 3745-3749
Abstract
The influence of different levels of dietary polyunsaturated fatty acids (PUFA) on the immune system and tumor growth were studied in young mice. Female BALB/c mice fed a PUFA-rich diet display an enhanced body growth, proliferative response to mitogens in vitro and rate of growth of a spontaneous transplantable adenocarcinoma as compared to PUFA-poor diet-fed females. Such effects are, however, limited by sex and strain background genes located outside the H-2 complex. The influence of dietary PUFA content is evident in female but not in male BALB/c mice. Moreover, in female DBA/2 mice with the same haplotype (H-2d) of the major histocompatibility complex as that of BALB/c mice, low dietary PUFA determines a reduced tumor growth only, but it does not affect body growth and proliferative response to mitogens in vitro.

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