Anetoderma. Clinical findings, associations, and long-term follow-up evaluations

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Abstract
In 16 patients with anetoderma, a clinicohistologic entity related to a local dermal defect of elastic tissue, old lesions did not heal and new lesions often continued to form for many years despite various forms of treatment. Systemic lupus erythematosus, which occurred in 1 patient, must be ruled out in patients with anetoderma. Discoid lupus erythematosus occurred later in 1 patient. Other associated findings, noted in 1 patient each, included cataract, congenital hip dislocation, congenital fusion of the vertebrate at [cervical] C2-3, diverticulum of the midesophagus, Addison''s disease (before the onset of anetoderma) and mitral valve prolapse. Patients with anetoderma must be examined for associated eye, bone, heart, pulmonary, digestive tract and endocrine abnormalities for a better assessment of their skin disorders.