ÜBER DIE BEDEUTUNG DER SCHILDDRÜSE FÜR DAS AUFTRETEN VON ERHÖHTEN SERUM-CHOLESTERINWERTEN BEI RATTEN NACH FÜTTERUNG VON N1-SULFANILYL-N2-N-BUTYLCARBAMID (BZ 55)

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Abstract
The daily oral administration to rats of BZ 55, (carbutamide), 0.5 g/kg body weight, caused hypercholesterolemia, hypoglycemia and a loss in body weight. Corresponding alterations were produced in rats by thyroidectomy. In thyroidectomized rats, administration of BZ 55 caused only an increased reduction of blood sugar values but did not further affect serum cholesterol or body weight values. It is concluded that the increase of the serum cholesterol values induced by BZ 55 is a result of its thyrostatic effect.