Xenobiotic triglyceride formation

Publisher Website
Google Scholar
Abstract
When 3-phenoxy[14C]benzoic acid was dosed orally (0.74 mg/kg) to rats, 1-3% of the administered radioactivity was found in the skin 4 days after dosing. Approximately 90% of this residue was unchanged 3-phenoxybenzoate; 10% was a neutral compound. The residue in the skins of rats dosed with 193 mg of 3-phenoxybenzoic acid over 7 days (about 100 mg/kg per day) contained 40% 3-phenoxybenzoate and 60% neutral metabolites. The components were separated and purified by gel permeation, absorption and TLC and analyzed by mass spectrometry. 2- and 3-(3-Phenoxybenzoyl)dipalmitins were major components of the neutral metabolite.